Capoten prescription
You may need Capoten prescription, so you have to
learn some important
facts beforehand. Your doctor can make Capoten prescription
for you.
After oral administration of therapeutic
doses of Capoten, rapid absorption occurs with peak
blood levels at
about one hour. The presence of food in the gastrointestinal tract
reduces absorption by about 30 to 40 percent; capoten therefore
should be given one hour before meals. Based on carbon-14 labeling,
average minimal absorption is approximately 75 percent. In a 24-hour
period, over 95 percent of the prescribed dose is eliminated in the
urine; 40 to 50 percent is unchanged drug; most of the remainder is the
disulfide dimer of captopril and captopril-cysteine disulfide.
Some patients with renal disease, particularly those who have got Capoten
prescription, have developed increases in BUN and
serum creatinine after reduction of blood pressure with captopril.
Prescribed
Capoten dosage reduction and/or discontinuation of diuretic may be
required. Tachycardia, chest pain, and palpitations have each been
observed in
approximately 1 of 100 patients. For some of these patients, it may not
be possible to
normalize blood pressure and maintain adequate renal perfusion.
Because of the potential fall in blood pressure in these patients,
prescription therapy should be started under very close medical
supervision. A
starting prescribed dose of 6.25 or 12.5 mg tid may minimize the
hypotensive
effect. Patients should be followed closely for the first two weeks of
treatment and whenever the dose of Capoten prescription
is
increased. In patients with heart failure, reducing the dose of
diuretic, if feasible, may minimize the fall in blood pressure.
Angioedema involving the extremities, face,
lips, mucous membranes, tongue, glottis or larynx has been seen in
patients treated with ACE inhibitors, including prescription Capoten.
If
angioedema involves the tongue, glottis or larynx, airway obstruction
may occur and be fatal. Angina pectoris, myocardial infarction,
Raynaud's syndrome, and
congestive heart failure have each occurred in 2 to 3 of 1000 patients.
Emergency therapy, including but not
necessarily limited to, subcutaneous prescription of a 1:1000
solution of epinephrine should be promptly instituted.
Agents Affecting Sympathetic Activity: The sympathetic nervous system
may be especially important in supporting blood pressure in patients
receiving captopril alone or with diuretics. Cardiovascular:
Hypotension may occur; see WARNINGS and PRECAUTIONS.
DRUG INTERACTIONS for discussion of hypotension with captopril therapy.
Therefore, agents
affecting sympathetic activity (e.g., ganglionic blocking agents or
adrenergic neuron blocking agents) should be used with caution.
Beta-adrenergic blocking drugs add some further antihypertensive effect
to Capoten, but the overall response is less than
additive.
Left Ventricular Dysfunction After Myocardial Infarction: The
recommended dose for long-term use in patients following a myocardial
infarction is a target maintenance dose of 50 mg tid.
Therapy may be initiated as early as three days following a myocardial
infarction. After a single dose of 6.25 mg, Capoten
prescription therapy should be
initiated at 12.5 mg tid. Capoten prescription should
then be increased to 25 mg tid
during the next several days and to a target dose of 50 mg tid over the
next several weeks as tolerated.
Capoten prescription is available in
potencies of 12.5 mg, 25 mg, 50 mg, and 100 mg
as scored tablets for oral administration. Inactive ingredients:
microcrystalline cellulose, corn starch, lactose, and stearic acid.
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