Buy Capoten online
Brand name: Capoten
Generic name: Captopril
Capoten (captopril tablets)
is a specific competitive inhibitor of
angiotensin I-converting enzyme (ACE), the enzyme responsible for the
conversion of angiotensin I to angiotensin II.
Captopril is a white to off-white
crystalline powder that may have a
slight sulfurous odor; it is soluble in water (approx. 160 mg/ mL),
methanol, and ethanol and sparingly soluble in chloroform and ethyl
acetate.
Capoten is available in potencies of 12.5
mg, 25 mg, 50 mg, and 100 mg
as scored tablets for oral administration. Inactive ingredients:
microcrystalline cellulose, corn starch, lactose, and stearic acid.
Capoten is indicated for the treatment of
hypertension. Capoten is
indicated in the treatment of congestive heart failure usually in
combination with diuretics and digitalis. The beneficial effect of
captopril in heart failure does not require the presence of digitalis,
however, most controlled clinical trial experience with captopril has
been in patients receiving digitalis, as well as diuretic treatment.
Capoten may be used as initial therapy for
patients with normal renal
function, in whom the risk is relatively low. In patients with impaired
renal function, particularly those with collagen vascular disease,
captopril should be reserved for hypertensives who have either
developed unacceptable side effects on other drugs, or have failed to
respond satisfactorily to drug combinations.
Capoten is effective alone and in
combination with other
anti-hypertensive agents, especially thiazide-type diuretics. The blood
pressure lowering effects of captopril and thiazides are approximately
additive.
The initial dose of Capoten (captopril tablets)
is 25 mg bid or
tid. If satisfactory reduction of blood pressure has not been achieved
after one or two weeks, the dose may be increased to 50 mg bid or tid.
Concomitant sodium restriction may be beneficial when Capoten
is used
alone.
The dose of Capoten in hypertension usually does not
exceed 50 mg tid.
Therefore, if the blood pressure has not been satisfactorily controlled
after one to two weeks at this dose, (and the patient is not already
receiving a diuretic), a modest dose of a thiazide-type diuretic (e.g.,
hydrochlorothiazide, 25 mg daily), should be added. The diuretic dose
may be increased at one to two-week intervals until its highest usual
antihypertensive dose is reached.
The adverse effect and pharmacokinetic limitations of Capoten
stimulated the development enalapril and subsequent ACE inhibitors.
These were specifically designed to lack the sulfhydryl moiety believed
to be responsible for rash and taste disturbance (Patchett et al.,
1980). Most subsequent ACE inhibitors are given as prodrugs, to improve
oral bioavailability. All have a longer half-life and are given once or
twice daily, which may improve patient compliance.
Cough is the most common long-therm adverse drug reaction associated
with Capoten therapy, as it is with all the ACE
inhibitors.
Hypotension is also a possible adverse effect, if the dose is too high.
Hyperkalemia is possible, due to ACE inhibition reducing aldosterone
production.
Patients should be advised to immediately report to their physician any
signs or symptoms suggesting angioedema (e.g., swelling of face, eyes,
lips, tongue, larynx and extremities; difficulty in swallowing or
breathing; hoarseness) and to discontinue therapy.
Patients should be told to report promptly any indication of infection
(e.g., sore throat, fever), which may be a sign of neutropenia, or of
progressive edema which might be related to proteinuria and nephrotic
syndrome.
All patients should be cautioned that excessive perspiration and
dehydration may lead to an excessive fall in blood pressure because of
reduction in fluid volume. Other causes of volume depletion such as
vomiting or diarrhea may also lead to a fall in blood pressure;
patients should be advised to consult with the physician.
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